Publication detail

Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types

Year: 2016

Type of publication: článek v odborném periodiku

Name of source: Natural Product Communications

Publisher name: Natural Products Inc.

Place: Westerville

Page from-to: 753-756

Titles:

Language	Name	Abstract	Keywords
cze	Cytotoxicita přirozeně se vyskytujících isochinolinových alkaloidů různých strukturních typů	Tato práce popisuje cytotoxicitu čtyřiceti šesti přirozeně se vyskytujících isochinolinových alkaloidů vůči nádorovým buněčným liniím a normálním lidským fibroblastům.	Isochinolinové alkaloidy; Skoulerin; Cytotoxicita; Caco-2; Hep-G2; MRC-5
eng	Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types	Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 +/- 0.87 and 4.57 +/- 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells.	Isoquinoline alkaloids; Scoulerine; Cytotoxicity; Caco-2; Hep-G2; MRC-5

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