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Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents
Authors: Mrózek Ondřej | Šebestová Lucie | Vinklárek Jaromír | Řezáčová Martina | Eisner Aleš | Růžičková Zdeňka | Honzíček Jan
Year: 2016
Type of publication: článek v odborném periodiku
Name of source: European Journal of Inorganic Chemistry
Page from-to: 519-529
Titles:
Language Name Abstract Keywords
cze Cyklopentadienylové a indenylové komplexy molybdenu rozpustné ve vodě - druhá generace cytotoxických sloučenin molybdenu Práce popisuje přípravu cyklopentadienylových a indenylových komplexů molybdenu s alkylammoniovými funkčními skupinami a jejich charakterizaci analytickými a spektroskopickými metodami. Struktury komplexů [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) a [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) byly urřený RTG strukturní analýzou. Připravené komplexy vykazují aktivitu vůči leukemizkým buněčným liniím MOLT-4 a HL-60. Jsou přibližně o jeden řád účinnější než cisplatina. molybden; indenyl; cytotoxicita
eng Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents A series of the cyclopentadienyl and indenyl molybdenum compounds bearing alkylammonium functions [(eta(5)-Cp')Mo(CO)(2)(L-N,L-N)][BF4](2) were synthesized and characterized by analytical and spectroscopic methods. The structures of [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) and [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) were determined by X-ray crystallography. All of the synthesized compounds exhibit high activity against the human leukemia cell lines MOLT-4 and HL-60. They are approximately one order of magnitude more active than cisplatin. This study has proven that the modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for the design of new highly cytotoxic active species. molybdenum; indenyl; cytotoxicity

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