Publication detail

Fused 1,4-dihydroquinolines and quinolinium perchlorates – From enamino compounds to tricyclic systems.

Authors: Brož Břetislav | Šimůnek Petr | Růžičková Zdeňka

Year: 2016

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Fused 1,4-dihydroquinolines and quinolinium perchlorates – From enamino compounds to tricyclic systems.	A simple method for synthesis of [1,2-a]-fused tricyclic dihydroquinolines was developer involving an intramolecular Buchwald-Hartwig amination reaction of suitable halogenated (both bromo and chloro) cyclic enaminoketones, enaminoesters and enaminonitriles with various ring size (from five- to seven-membered). Optimal reaction conditions (palladium source, base, ligand) depend on the ring size of the starting enamine, giving 65-98% yield of the tricyclic product. A treatment of the products with perchloric acid gives respective quinolinium perchlorates.

Search