Login for students

Login for employees

Publication detail

DETERMINATION OF DISTRIBUTION CONSTANTS OF ANTIOXIDANTS BETWEEN LIPOSOMES, ALKYLSULFATE MICELLES, OCTANOL AND WATER USING ELECTROKINETIC CHROMATOGRAPHY
Authors: Váňová Jana | Liimatta Laura J. | Česla Petr | Wiedmer Susanne K.
Year: 2016
Type of publication: ostatní - přednáška nebo poster
Page from-to: nestránkováno
Titles:
Language Name Abstract Keywords
eng DETERMINATION OF DISTRIBUTION CONSTANTS OF ANTIOXIDANTS BETWEEN LIPOSOMES, ALKYLSULFATE MICELLES, OCTANOL AND WATER USING ELECTROKINETIC CHROMATOGRAPHY The in vivo effects of the antioxidants are dependent on their lipophilicity, which govern membrane and protein interactions. Two electrokinetic systems, i.e. micellar electrokinetic chromatography (MEKC) and liposome electrokinetic chromatography (LEKC), were used for studying of the lipophilicity of antioxidants. Micelles of sodium decyl sulfate (SDeS) and sodium dodecyl sulfate (SDS) were used as the pseudostationary phase in MEKC and the liposomes were composed of mixtures of 1-palmitoyl-2-oleyl-sn-glycerophosphatidylcholine (POPC) and 1-palmitoyl-2-oleoyl-sn-phosphatidylserine (POPS) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl-DL-glycerol (POPG) in LEKC. The retention factors of the studied analytes were determined at pH 7.4. The micelle and liposome/aqueous distribution constants for studied antioxidants were experimentally determined and compared with values of octanol/aqueous distribution constants.

Departments

Other Parts

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0Creative CommonsAttributionNonCommercialNoDerivatives