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Amidophosphine-stabilized palladium complexes catalyse Suzuki-Miyaura cross-couplings in aqueous media
Authors: Jansa Josef | Reznicek Tomas | Dostál Libor | Růžičková Zdeňka | Bureš Filip | Jambor Roman
Year: 2016
Type of publication: článek v odborném periodiku
Name of source: Applied Organometallic Chemistry
Publisher name: John Wiley & Sons Ltd.
Place: Chichester
Page from-to: 1036-1042
Titles:
Language Name Abstract Keywords
cze Pd komplexy jako katalyzátory ve vodném prostředí Byla zjištěna efektivní procedura pro Suzuki-Miyaura reackci ve vodném prostředí. Pro tento účel byly připraveny Pd komplexy trans-{(LPPh2)-P-3}(2)PdCl2 (3), trans-{L(3)PPhtBu}(2)PdCl2 (4), [Pd(eta(3)-C3H5)((LPPh2)-P-3)Cl] (5) a {Pd[2-(Me2NCH2)C6H4]((LPPh2)-P-3)Cl} (6). Pd komplexy; Suzuki-Miyaura; katalyzátory; vodné prostředí
eng Amidophosphine-stabilized palladium complexes catalyse Suzuki-Miyaura cross-couplings in aqueous media We report a simple and efficient procedure for Suzuki-Miyaura reactions in aqueous media catalysed by amidophosphine-stabilized palladium complexes trans-{(LPPh2)-P-3}(2)PdCl2 (3), trans-{L(3)PPhtBu}(2)PdCl2 (4), [Pd(eta(3)-C3H5)((LPPh2)-P-3)Cl] (5) and {Pd[2-(Me2NCH2)C6H4]((LPPh2)-P-3)Cl} (6). The acidity of the NH proton in complexes 3-6 plays an important role in their catalytic activity. In addition, the palladium complexes cis-{(LPPh2)-P-1}PdCl2 (1) and trans-{(LPPh2)-P-2}(2)PdCl2 (2) stabilized by phosphines containing Y, C, Y-chelating ligands L-1,L-2 have also been found to be useful catalysts for Suzuki-Miyaura reactions in aqueous media. The method can be effectively applied to both activated and deactivated aryl bromides yielding high or moderate conversions. The catalytic activity of couplings performed in pure water increases when utilizing a Pd complex with more acidic NH protons. A decrease of palladium concentration from 1.0 to 0.5 mol% does not lead to a substantial loss of conversion. In addition, Pd complex 1 can be efficiently recovered using two-phase system extraction. aqueous media; palladium; Suzuki-Miyaura; C C coupling

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