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Modified cyclopentadienyl molybdenum compounds with enhanced cytotoxic activity towards MOLT-4 leukaemia cells
Authors: Klepalová Iva | Vinklárek Jaromír | Růžičková Zdeňka | Řezáčová Martina | Honzíček Jan
Year: 2017
Type of publication: článek v odborném periodiku
Name of source: Applied Organometallic Chemistry
Publisher name: John Wiley & Sons Ltd.
Place: Chichester
Page from-to: "e3759-1"-"e3759-10"
Titles:
Language Name Abstract Keywords
cze Modifikované cyklopentadienylové sloučeniny molybdenu se zvýšenou cytotoxickou aktivitou vůči leukemickým buňkám MOLT-4 Byla připravena série nových cyklopentadienylových sloučenin molybdenu se substituovanými fenentrolinovými ligandy[(eta(5)-C5H4CH2C6H4X-4)Mo(CO)(2)(L-N,L-N)][BF4] (X = F, Cl, Br; L-N,L-N=phen, 5-NH2-phen, 4,7-Ph-2-phen). Tyto sloučeniny byly characterizovány infračervenou a NMR spektroskopií. Krystalové struktury [(eta(5)-C5H4CH2C6H4F-4)Mo(CO)(2)(NCMe)(2)][BF4], [(eta(5)-C5H4CH2C6H4X-4)Mo(CO)(2)(phen)][BF4] (X = F, Cl, Br) a [(eta(5)-C5H4CH2C6H4Cl-4)Mo(CO)(2)(4,7-Ph-2-phen)][BF4](4,7-Ph-2-phen)HBF4 byly učeny RTG-difrakční analýzou. Biologické testy ukázaly silnou závislost cytotoxické aktivity na chelátujícím ligandu. cyklopentadienyl; cytotoxicita; fulven; leukemie; molybden; RTG-analýza
eng Modified cyclopentadienyl molybdenum compounds with enhanced cytotoxic activity towards MOLT-4 leukaemia cells A series of new cyclopentadienyl molybdenum compounds bearing substituted phenanthroline ligands [(eta(5)-C5H4CH2C6H4X-4)Mo(CO)(2)(L-N,L-N)][BF4] (X = F, Cl, Br; L-N,L-N=phen, 5-NH2-phen, 4,7-Ph-2-phen) was prepared and characterized using infrared and NMR spectroscopies. Crystal structures of [(eta(5)-C5H4CH2C6H4F-4)Mo(CO)(2)(NCMe)(2)][BF4], [(eta(5)-C5H4CH2C6H4X-4)Mo(CO)(2)(phen)][BF4] (X = F, Cl, Br) and [(eta(5)-C5H4CH2C6H4Cl-4)Mo(CO)(2)(4,7-Ph-2-phen)][BF4](4,7-Ph-2-phen)HBF4 were determined using X-ray diffraction analysis. Biological studies revealed a strong cytotoxic effect of the chelating ligands. Although the cytostatic effect of the halogen in the side chain of the cyclopentadienyl ring is negligible, it could be used for future post-modification of these types of cytotoxic active molybdenum-based compounds. cyclopentadienyl; cytotoxicity; fulvene; leukaemia therapy; molybdenum; X-ray diffraction analysis

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