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Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode
Authors: Štěpánková Michaela | Šelešovská Renáta | Janíková Lenka | Chýlková Jaromíra
Year: 2017
Type of publication: článek v odborném periodiku
Name of source: Chemical Papers
Page from-to: 1419-1427
Titles:
Language Name Abstract Keywords
cze Voltametrické stanovení mesalazinu ve farmaceutických přípravcích s využitím borem dopované diamantové elektrody Bylo studováno voltametrické chování mesalazinu na borem dopované diamantové elektrodě a byla vyvinuta metoda jeho stanovení. Ta byla aplikována při analýze farmaceutických přípravků a moči. Mesalazin; borem dopovaná diamantová elektroda; square wave voltametrie; farmaceutické přípravky, moč
eng Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode Voltammetric method for the determination of non-steroidal anti-inflammatory drug mesalazine (5-ASA) is presented for the first time using boron-doped diamond electrode (BDDE). 5-ASA provides one well-developed SWV oxidation peak at about -900 mV (vs. saturated silver/silver chloride reference electrode) on BDDE. Britton-Robinson buffer (pH 7.0) was chosen as an optimal supporting electrolyte for the determination of 5-ASA using square wave voltammetry (SWV). Parameters of SWV were developed and low limit of detection (7.0 9 10-7 mol L-1) was reached. In addition, relative standard deviation of repeated measurements (c5-ASA = 5 9 10-5 mol L-1, RSDM = 2.7%) and relative standard deviation of repeated determinations (RSDD \ 1.5%) were calculated and confirm obtained good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation and spiked human urine. Mesalazine; Boron-doped diamond electrode; Square wave voltammetric determination; Pharmaceutical preparation; Urine

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