Publication detail

Voltammetric determination of leucovorin in pharmaceutical samples

Authors: Martinková Pavlína | Kränková Barbora | Šelešovská Renáta | Janíková Lenka

Year: 2017

Type of publication: článek ve sborníku

Name of source: 13th ISC Modern Analytical Chemistry

Publisher name: Univerzita Karlova. Přírodovědecká fakulta

Place: Praha

Page from-to: 210-215

Titles:

Language	Name	Abstract	Keywords
cze	Voltametrické stanovení leukovorinu ve farmaceutických přípravcích	Voltametrické chování leukovorinu bylo studováno na borem dopované diamantové elektrodě a byla vyvinuta metoda stanovení tohoto léčiva. Ta byla úspěšně aplikována při analýze injekčního roztoku.	Leukovorin; Oxidace; borem dopovaná diamantová elektroda; diferenční pulzní voltametrie
eng	Voltammetric determination of leucovorin in pharmaceutical samples	Voltammetric behavior of leucovorin has been investigated for the first time using boron-doped diamond electrode (BDDE) and the method for its determination was developed. Leucovorin provides two well-developed oxidation peaks at about +900 and +1450 mV (pH 5) on BDDE. Britton-Robinson buffer (pH 3.0) was chosen as an optimal supporting electrolyte for its determination using differential pulse voltammetry (DPV) with optimized parameters. Limit of detection 1.5×10−8 mol L−1 was reached for leucovorin determination and linear dynamic range 1.5×10−7-2.5×10−5 M was obtained. Relative standard deviation of repeated measurements (RSDM(11) = 0.7 %) and relative standard deviations of repeated determinations (RSDD(5) < 3.0 %) were calculated to confirm very good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation.	Leucovorin; Oxidation; Boron-doped diamond electrode; Differential pulse voltammetry

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