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Comparison study of voltammetric determination of mesalazine using boron-doped diamond electrodes with different content of boron
Authors: Štěpánková Michaela | Šelešovská Renáta | Janíková Lenka | Marton Marián | Michniak Pavol
Year: 2017
Type of publication: ostatní - článek ve sborníku
Name of source: YISAC 2017 24th Young Investigators Seminar on Analytical Chemistry : book of abstracts
Publisher name: Ca’ Foscari University of Venice
Place: Benátky
Page from-to: 32
Titles:
Language Name Abstract Keywords
eng Comparison study of voltammetric determination of mesalazine using boron-doped diamond electrodes with different content of boron Mesalazine (5-amino-2-hydroxybenzoic acid) is well-established compound used in the management of inflammatory bowel disease (IBD). Mesalazine is an active moiety of sulfasalazine drug, which is metabolized to sulfapyridine and mesalazine. Mesalazine, as an antioxidant, traps free radicals, which are potentially damaging by products of metabolism. The pure diamond is distinguished by outstanding mechanical and chemical stability and it is one of the best natural insulators. For its electrochemical utilization, it needs to be doped with atoms of other elements, most often with boron. Boron-doped diamond electrode (BDDE) has been firstly described in the eighties of previous century. It is substantiated by its superior physical, mechanical, and electrochemical properties, such as wide potential window, thermal conductivity, chemical stability, and stable and low background current. The boron content in BDD is one of the factors influencing substantially the film conductivity and morphology. The concentration of boron also significantly influences the electrochemical properties of the BDD films. Obviously, increased boron content leads to higher capacitance, slightly narrower solvent windows, and can increase the likelihood of undesirable incorporation of sp2 impurities. In this study, mesalazine drug was used for investigation and comparison of application possibilities of BDDE with different content of boron.

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