Publication detail

New and efficient synthesis of tyrosin kinase inhibitors containing 3-(amino(aryl)methylidene)-1,3-dihydro-2H-indol-2-one moiety

Authors: Hanusek Jiří | Marek Lukáš

Year: 2018

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	New and efficient synthesis of tyrosin kinase inhibitors containing 3-(amino(aryl)methylidene)-1,3-dihydro-2H-indol-2-one moiety	In our group we developed new synthetic method starting from easily available 5- or 6-substituted 3-bromo oxindoles and 3- or 4- substituted thiobenzamides. These components react in polar aprotic solvent (acetonitrile, DMF) to give desired 3-[amino(aryl)-methylidene]-1,3-dihydro-2H-indol-2-one in good to excellent yield. The reaction mechanism involving Eschenmoser coupling was also studied.	synthesis; tyrosin kinase inhibitors; 3-aminoarylmethylidene-1,3-dihydro-2H-indol-2-ones;

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