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Contribution to the rheological testing of pharmaceutical semisolids
Authors: Šiška Bedřich | Šnejdrová Eva | Machač Ivan | Doleček Petr | Martiška Juraj
Year: 2018
Type of publication: článek v odborném periodiku
Name of source: Pharmaceutical Development and Technology
Page from-to: 80-88
Titles:
Language Name Abstract Keywords
cze Příspěvek k reologickému testování farmaceutických polotuhých látek Práce se zabývá reologickým testováním farmaceutických polotuhých látek. K popisu reologického chování modelových látek byly využity reologické testy jako např. rotační, oscilační, krípové testy se zotavením, tixotropní atd. Polotuhé látky; mez skluzu; tixotropie; penetrometrie; adheze; viskoelasticita
eng Contribution to the rheological testing of pharmaceutical semisolids Rheological behaviour of pharmaceutical semisolid preparations significantly affects manufacturing pro- cess, administration, stability, homogeneity of incorporated drug, accuracy of dosing, adhesion in the place of application, drug release, and resulting therapeutic effect of the product. We performed test of consistency by penetrometry, rotational, oscillation and creep tests, and squeeze and tack tests of model samples to introduce methods suitable for characterization and comparison of semisolids in practice. Penetrometry is a simple method allowing sorting the semisolids to low and high stress-resistant materials but deficient for rheological characterization of semisolids. Value of yield stress, generally considered to be appropriate feature of semisolids, is significantly influenced by the method of testing and the way of evaluation. The hysteresis loops of model semisolids revealed incomplete thixotropy, therefore, three-step thixotropy test was employed. Semisolids showed nonlinear response in the creep phase of tests and par- tial recovery of structure by storing energy in the recovery phase. Squeeze and tack tests seem to be con- venient ways for comparison of semisolids. Our study can contribute to a better understanding of different flow behaviour of semisolids given by different physicochemical properties of excipients and can bring useful approaches to evaluation and comparison of semisolids in practice. Semisolids; yield stress; thixotropy; penetrometry; adhesion; viscoelasticity

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