Publication detail

Synthesis, characterization and cytotoxic activity of vanadocene dithiocarbamate complexes

Authors: Machálková Aneta | Melounková Lucie | Vinklárek Jaromír | Císařová Ivana | Honzíček Jan

Year: 2019

Type of publication: článek v odborném periodiku

Name of source: Inorganica Chimica Acta

Publisher name: Elsevier Science SA

Place: Lausanne

Page from-to: 125-130

Titles:

Language	Name	Abstract	Keywords
cze	Příprava charakterizace a cytotoxicita dithiokarbamátových vanadocenovch komplexů	Tato studie popisuje přípravu ve vodě rozpustných komplexů vanadocenu a dimethylvanadocenu s dithiokarbamátovými ligandy. Tyto komplexy byly charakterizovány analytickými a spektroskopickými metodami. Jejich cytotoxicita byla studována na leukemických buňkách MOLT-4.	Metallocen; vanad; EPR spektroskopie; cytotoxicita
eng	Synthesis, characterization and cytotoxic activity of vanadocene dithiocarbamate complexes	This study describes synthesis of water-soluble vanadocene and 1,1'-dimethylvanadocene compounds bearing dithiocarbamate ligands. All prepared compounds were characterized by analytical and spectroscopic methods. The structure of [(eta(5)-C5H4Me)(2)V{S2CN(CH2)(4)O}]Cl was determined by single-crystal X-ray diffraction analysis. The cytotoxicity of the synthesized compounds was investigated on human leukemia cells MOLT-4. The derivatives bearing cyclic dithiocarbamates show considerably stronger activity than reported for cisplatin.	Metallocene; Vanadium; S,S-Chelating ligands; EPR spectroscopy; Cytotoxicity

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