Publication detail

Antistaphylococcal Activity of New Salicylamide Analogues

Authors: Michnová Hana | Imramovský Aleš | Magar Pratibha | Čížek Alois | Jampílek Josef

Year: 2019

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Antistaphylococcal Activity of New Salicylamide Analogues	Antimicrobial resistance is still a serious global threat. Staphylococcus aureus is a common cause of severe infections in health facilities and the community. People with methicillinresistant S. aureus (MRSA) are estimated to be 64% more likely to die than people with a nonresistant form of the infection. For that reason, the research and development of new active compounds is really needed. Salicylamides are anti-infectious agents with a wide range of pharmacological effects, such us antiviral, antibacterial, antifungal and anthelminthic. Thus, derivatives of this group are very promising compounds. A series of newly synthesized complex salicylamide derivatives was tested for their antimicrobial effect against methicillin-resistant Staphylococcus aureus (MRSA). Staphylococcus aureus ATCC 29213 as a control and three isolates of MRSA were used. The activity was assessed by the evaluation of minimum inhibitory concentration. Using the microdilution method with subcultivation of aliquots, the minimum bactericidal concentration was determined too. Ciprofloxacin and ampicillin were used as standard antibacterial drugs. Four most promising compounds from the series were chosen and are demonstrated in this contribution.	Antibacterial Activity; Staphylococcus aureus; MRSA; Salicylamide

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