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Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
Authors: Hulcova Daniela | Marikova Jana | Korabecny Jan | Hostalkova Anna | Jun Daniel | Kunes Jiri | Chlebek Jakub | Opletal Lubomir | De Simone Angela | Novakova Lucie | Andrisano Vincenza | Růžička Aleš | Cahlikova Lucie
Year: 2019
Type of publication: článek v odborném periodiku
Name of source: Phytochemistry
Publisher name: Elsevier Science BV
Place: Amsterdam
Page from-to: "112055-1"-"112055-9"
Titles:
Language Name Abstract Keywords
cze Alkaloidy Amaryllidaceae z Narcissus pseudonarcissus L. cv. Dutch Master jako potenciální drogy v léčbě Alzheimerovy choroby Z čerstvých cibulí Narcissus pseudonarcissus L. cv bylo izolováno dvacet jedna známých alkaloidů Amaryllidaceae různých strukturních typů a jeden neopsaný alkaloid, nazvaný narcimatulin. Holandský mistr. Chemické struktury byly objasněny kombinací MS, HRMS, 1D a 2D NMR spektroskopických technik a porovnáním s údaji z literatury. Narcimatulin amalgamuje ve svém jádru dvě základní lešení alkaloidů Amaryllidaceae, jmenovitě galanthamin a galanthindole. Všechny izolované sloučeniny byly hodnoceny na in vitro inhibiční účinky na acetylcholinesterázu (AChE), butyrylcholinesterázu (BuChE), prolyl oligopeptidázu (POP) a glykogen syntázu kinázu-3 beta (GSK-3 beta). Nejzajímavější biologický profil byl prokázán nově izolovaným alkaloidním narcimatulinem. Alkaloidy; Amaryllidaceae; Narcissus pseudonarcissus; Narcimatulin; Alzheimerova choroba
eng Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease Twenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical structures were elucidated by combination of MS, HRMS, 1D and 2D NMR spectroscopic techniques, and by comparison with literature data. Narcimatuline amalgamates two basic scaffolds of Amaryllidaceae alkaloids in its core, namely galanthamine and galanthindole. All isolated compounds were evaluated for their in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), prolyl oligopeptidase (POP), and glycogen synthase kinase-3 beta (GSK-3 beta) inhibitory activities. The most interesting biological profile was demonstrated by newly isolated alkaloid narcimatuline. Narcissus pseudonarcissus L. cv. Dutch master; Amaryllidaceae; Alkaloids; Narcimatuline; Alzheimer's disease; Cholinesterase inhibition; Glycogen synthase kinase-3 beta inhibition; Prolyl oligopeptidase