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Wound healing of different molecular weight of hyaluronan; in-vivo study
Authors: Fouda Moustafa M. G. | Abdel-Mohsen A. M. | Ebaid Hossam | Hassan Iftekhar | Al-Tamimi Jameel | Abdel-Rahman Rasha | Metwalli Ali | Alhazza Ibrahim | Rady Ahmed | El-Faham Ayman | Jancar J.
Year: 2016
Type of publication: článek v odborném periodiku
Name of source: International Journal of Biological Macromolecules
Publisher name: Elsevier Science BV
Place: Amsterdam
Page from-to: 582-591
Titles:
Language Name Abstract Keywords
cze Wound healing of different molecular weight of hyaluronan; in-vivo study Paper deals with wound healing of different molecular weight of hyaluronan; in-vivo study.
eng Wound healing of different molecular weight of hyaluronan; in-vivo study Recruitment of cells and mediators is altered during impaired wound healing, thereby delaying this process. To overcome this problem, the correlation of wound healing in older rats, and the impact of different molecular weight of hyaluronan without silver nanoparticles; (low-HA1), (High-HA2), (Medium-HA3) and with silver nanoparticles (High-HA4) is investigated. The superior HA were selected to be further investigated onto diabetic wounds. Our results pointed to a marked deficiency in wounds granulation in older rats, which was accompanied with impairment of healing process. In older rats group treated with HA2 or HA4, granulation and dermal construction were improved. Furthermore, the number of pathogenic bacteria on wounds was declined throughout the first 24 h by HA2 and HA4. The wound size in HA4-treated older rats was significantly smaller than that in other HA1, HA2 or HA3-treated older ones. Also, diabetes impaired the level of inflammatory cytokine, in diabetic model. On contrary, HA4 was found to normalize the level of inflammatory cytokine, in the diabetic model. Furthermore, HA4 was found to recover all oxidative and toxicity markers in diabetic models. This data confirms the critical role of HA4 to improve granulation and inflammatory mediators in impaired older and diabetic rat wound healing. Wound healing; Hyaluronan; Animal models

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