University of PardubiceFaculty of Chemical Technology

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A stereoselective study of alfaprostol omega chain synthesis – application possibilities in the synthesis of intermediates.

Authors: Imramovský Aleš

Year: 2021

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	A stereoselective study of alfaprostol omega chain synthesis – application possibilities in the synthesis of intermediates.	Prostaglandins (PG) a well known compounds are a group of lipid mediators with multiple pharmaceutical and veterinary applications. These compounds also bring a significant economic effect to their producers. Synthesis of these compounds is performed by using old protocols with multistep reaction procedures.1 For this reason, we investigated a several possibilities of synthetic Prostaglandin F2α methyl ester analogue – Alfaprostol. This molecule contains, in comparison with other PG, propargyl moiety in omega chain. This moiety is well discussed in literature. Over past decade a huge number of studies described formation of propargyl moiety with or without stereospecific aspects of this reaction were described.2 For this reason, we investigated this reaction in lab scale and further on its possibility to apply in chemical industry. Classical approach to Alfaprostol omega chain (literature) and our novel methodology for this organic specialties will be discussed.	stereoselective synthesis; alfaprostol; prostaglandins