University of Pardubice Faculty of Chemical Technology

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Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in renal cell carcinoma patients

Authors: Jirásko Robert | Idkowiak Jakub | Wolrab Denise | Kvasnička Aleš | Friedecký David | Polański Krzysztof | Študentová Hana | Študent Vladimír | Brabcová Ivana | Melichar Bohuslav | Holčapek Michal

Year: 2021

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in renal cell carcinoma patients	Renal cell carcinoma (RCC) represents the most common type of kidney cancer with the highest incidence and mortality rate among all urological malignancies. Biochemical processes related to RCC result in an altered lipidomic profile in body fluids that can be helpful for early cancer detection. However, the application of reliable quantitative analysis is necessary to reveal these alternations. In this work, we analyzed 599 plasma, urine, and tissue samples from 368 of RCC patients and healthy controls. Mass spectrometry-based profiling of sulfatides and sphingomyelins in plasma and urine samples shows appreciable concentration changes in renal cell carcinoma patients compared with healthy controls. Elevated concentrations of lactosylsulfatides, decreased concentration level of sphingomyelines with long saturated N-fatty acyls and sulfatides with hydroxylated fatty acyls show to be the most important dysregulations in cancer. The positive correlation between the results obtained for body fluids and tissues indicates that the altered sphingolipid profile is closely associated with tumor progression.