University of PardubiceFaculty of Chemical Technology

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Diiminoisoindoles as powerful nitrogen-rich scaffold for coordination chemistry

Authors: Čiefová Stanislava | Švec Petr | Růžička Aleš

Year: 2022

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Diiminoisoindoles as powerful nitrogen-rich scaffold for coordination chemistry	Isoindole derivatives play an important role in many fields of chemistry. The isoindole fragment can be found in resistant pigments such as phthalocyanines1, pharmaceuticals but also in natural products as a part of alkaloids1. The preparation of substituted acyclic diiminoisoindoles is often time consuming, requires catalysis and achieves low yields.2 Therefore, the aim of our work is to prepare and characterize selected substituted diiminoisoindoles simply and in a good yield and then further investigate their reactivity. Targeted diiminoisoindoles were prepared by reaction of a substituted lithium amide with dicyanobenzene at low temperature in the form of lithium complexes (B). This process allows to obtain symmetrically but also asymmetrically substituted diiminoisoindoles. After hydrolysis, we were able to achieve further substitution by acyl halides (C) or addition reaction with carbodiimides (A). Prepared diiminoisoindoles were subsequently used as electron rich ligands systems for organometallic and coordination chemistry.