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Synthetic pathways towards fused pyrazine derivatives

Authors: Prokopová Eva | Bureš Filip | Burešová Zuzana | Klikar Milan

Year: 2023

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthetic pathways towards fused pyrazine derivatives	Pyrazine derivatives are well-known six membered aromatic heterocyclic compounds bearing two nitrogen atoms. To this day, several methods enabling synthesis of pyrazine are known. The most popular method utilized in construction of pyrazine ring involves condensation of 1,2-diamines with 1,2-dicarbonyl compounds (benzils). Hence, as a part of our ongoing research activity, we have explored a condensation reaction of 1,2-diamines (especially diaminomaleonitrile) with planar 1,2-diketones such as for example phenantrene-9,10-quinone or benzo[1,2-b;4,3-b´]dithiophene-4,5-quinonone). Variety of solvents, catalysts, bases and acids were screened in these condensations to probe their feasibility. Moreover, a reversed synthetic strategy was also attempted, which allowed to compare reactivity of electron-rich thiophene and benzene amines/ketones.	pyrazine; 1,2-diamines; 1,2-diketones; condensation