Publication detail

A New Hollow Fiber-Based Liquid-Phase Microextraction Method for The Determination of Antihypertensive Drug Lercanidipine in Biological Samples

Authors: Labzova Oleksandra | Hrdlička Vojtěch | Navrátil Tomáš | Šelešovská Renáta

Year: 2024

Type of publication: ostatní - článek ve sborníku

Name of source: 43rd Modern Electrochemical Methods :Proceedings of the International Conference

Publisher name: BEST Servis

Place: Ústí nad Labem

Page from-to: 116-120

Titles:

Language	Name	Abstract	Keywords
eng	A New Hollow Fiber-Based Liquid-Phase Microextraction Method for The Determination of Antihypertensive Drug Lercanidipine in Biological Samples	A new hollow fiber-based liquid-phase microextraction (HF-LPME) method for the determination of antihypertensive drug lercandipine (LCN) in biological samples was developed. HF-LPME was combined with optimized square wave voltammetry (SWV) on a cathodically pre-treated screen-printed boron-doped diamond electrode (SP-BDDE). Optimum HF-LPME conditions were: supported liquid membrane (SLM) dodecane, 0.02 mol L−1 Britton-Robinson buffer (BRB, pH = 3) acceptor phase, BRB (pH = 7) donor phase, and time of extraction 30 min. Limits of quantification (LOQ) and detection (LOD) were 3.3 and 1.1 nmol L−1, respectively. The applicability of the developed method was verified on human urine, blood serum, and blood plasma with 20 and 100 nmol L−1 LCN addition.	Lercanidipine hydrochloride, Hollow fiber liquid-phase microextraction, Screen-printed boron-doped diamond electrode, Square wave voltammetry

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