University of Pardubice Faculty of Chemical Technology

University

Employees
|
Students
Česky

Publication detail

Photodeuteration Of Aldehydes Catalyzed By DPZ

Authors: Grygarová Monika | Burešová Zuzana | Bureš Filip

Year: 2024

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Photodeuteration Of Aldehydes Catalyzed By DPZ	Deuteration of chemical compounds becomes of great importance in pharmaceutical, materials and synthetic chemistry. Deuterated drugs and biochemical compounds are currently essential for monitoring mechanisms and metabolic pathways. Due to metallic free structure, low cost, and low environmental impact, dicyanopyrazine photoredox catalysts (DPZs) are ideal catalysts for visible light mediated photoredox modification of biologically active substrates. In this work, DPZ based photocatalysts were used for photodeuteration of variously substituted aromatic and aliphatic aldehydes. The extent of deuteration using three DPZ photocatalysts was systematically investigated along with a set of blank experiments. These experiments combined with transient absorption spectroscopy and quantum-chemical calculations allowed to propose plausible mechanism of photochemical deuteration aldehydes catalysed by DPZ photocatalysts.	dikyanopyrazine; photoredox catalysis; deuteration