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TESTING OF THE DESINFECTANT ACTIVITY OF COMPOUNDS BASED ON BIODSEGRADABLE OLIGOMER

Authors: Baslerová Nikola | Olejník Roman | Pejchalová Marcela

Year: 2024

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	TESTING OF THE DESINFECTANT ACTIVITY OF COMPOUNDS BASED ON BIODSEGRADABLE OLIGOMER	The demand for disinfectants increased during the COVID-19 pandemic. However, their overuse and misuse has also increased. This can exacerbate the problem of antimicrobial resistance, but also have serious consequences for ecosystems and human health. An ideal disinfectant should be effective at low concentrations, be safe for human health and be effective against a wide range of micro-organisms. It should also be readily degradable, environmentally friendly, and inexpensive to produce, which lactic acid biopolymers could fulfil. Today, biopolymers are important mainly because they are renewable and non-toxic. In a normal laboratory, the bacterial effectiveness of a disinfectant can be demonstrated using the method described in the ČSN EN 13727+A2 standard. The first step was to determine the minimum inhibitory concentration (MIC) using the dilution method in 24-well plates. The MIC was determined for four microorganisms - Escherichia coli (CCM 4517), Staphylococcus aureus (CCM 4516), Pseudomonas aeruginosa (CCM 7930), Enterococcus hirae (CCM 4533). Thirteen substituted lactyl lactates synthesised at the Department of General and Inorganic Chemistry of the University of Pardubice were thus tested. Only one of them was further tested according to the ČSN EN 13727+A2 standard. The most promising sample was tested according to ČSN EN 13727+A2 standard in 1.5% and 2% concentration. The 2% concentration of the tested substance was not effective against Enterococcus hirae. At the same time, the sample was sent to an accredited EMPLA laboratory. There, according to the standard ČSN EN 13727+A2, the tested substance met the requirements for reduction in a 3% concentration. The tested sample shows a bactericidal effect even in a low concentration (3%) compared to, for example, alcohol (30%) or povidone-iodine, which is typically produced in a concentration of 7.5-10%.	disinfectant; ČSN EN 13727+A2 standard; biodegradable oligomers