Publication detail

A new hollow fiber liquid-phase microextraction method for determination of antidepressant drug trazodone in urine sample

Authors: Labzova Oleksandra | Hrdlička Vojtěch | Navrátil Tomáš | Matvieiev Oleksandr | Šelešovská Renáta

Year: 2025

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	A new hollow fiber liquid-phase microextraction method for determination of antidepressant drug trazodone in urine sample	A novel hollow fiber liquid-phase microextraction (HF-LPME) method combined with square wave voltammetry (SWV) on screen-printed boron-doped diamond electrodes (SP-BDDE) was developed for sensitive determination of the antidepressant trazodone (TRZ) in human urine. TRZ was extracted through an isoamyl benzoate-supported liquid membrane into an acidic acceptor solution, followed by voltammetric detection. Optimization of experimental parameters led to excellent sensitivity, with a detection limit of 20 nmol L-1 in urine—significantly lower than previously reported electrochemical methods. The method demonstrated high potential for clinical monitoring with minimal solvent use and material consumption.	trazodone, hollow fiber microextraction, voltammetry, boron-doped diamond electrode, urine analysis, antidepressants, green analytical method

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