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Synthesis of Biologically Active Arginine Derivatives Derived from Salicylamide

Authors: Šanda Martin | Imramovský Aleš

Year: 2025

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of Biologically Active Arginine Derivatives Derived from Salicylamide	Peptidomimetics represent a promising group of biologically active compounds with broad therapeutic potential that mimic naturally occurring peptides while overcoming their limitations. In this study, novel peptidomimetics derived from salicylic acid and arginine were designed, synthesized and characterized. The synthesis was carried out through stepwise building of the peptidomimetic scaffold via Steglich amidation, with subsequent side-chain functionalization by guanidylation affording selected arginine derivatives. In conclusion, synthetic approach was verified by repetition and compounds were isolated in quality suitable for biological testing.	Peptidomimetics; Biological Activity; Arginine; Salicylamide