University of PardubiceFaculty of Chemical Technology

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Incorporation of biologically active substances into polysaccharide-based fibers

Authors: Hrdina Radim | Burgert Ladislav | Honcová Pavla | Bayerová Petra | Černý Michal | Bouška Marek | Brožková Iveta | Moťková Petra | Vydržalová Markéta | Stará Ivana | Michalíčková Ludmila | Hrdina Jr. Radim | Belhajová Marie | Musil Zdeněk | Vícha Aleš | Moravec Tomáš | Netuka David

Year: 2025

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Incorporation of biologically active substances into polysaccharide-based fibers	The lecture addresses the issue of incorporating biologically active substances into polysaccharide-based fibers. Using specific examples, it discusses the types of bonds and interactions between a biologically active substance and the fiber, what this means for processing technologies, and what outcomes can be achieved. Cotton fibers (CO) and fibers made from sodium hyaluronate (HA) were selected as carriers of biologically active substances. Using dyes that simulated the structures of biologically active compounds, the fixation of dyes in the fibers via covalent and ionic bonds, as well as hydrophobic interactions, was studied. The results obtained provide insight into methods for incorporating biologically active substances into CO and HA fibers. The antimicrobial activity of the materials was tested using the agar diffusion method, which allows for a qualitative assessment of antimicrobial efficacy. The microorganisms tested were: E. coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and Candida albicans. The effects of the materials on the viability and proliferation of cancer cells were studied using the UKF-NB-4 neuroblastoma cell line and the U87 glioblastoma cell line. In the third part of the lecture, procedures leading to truly effective materials and the technological options for their production will be evaluated. The outcomes include cotton textiles with antimicrobial properties, suitable for producing, for example, protective garments. Another result is an invention (patent CZ 310 334 B6, 2025) concerning staple fibers of hyaluronic acid and its salts, optionally containing oxidized starch, cross-linked with temozolomide. These fibers are suitable for the treatment of brain tumors.	Biologically active; polysaccharide fibers, sodium hyaluronate, cotton fibers