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Submicron TiO₂ Rutile Fibers Exhibit No Toxic Effects in Zebrafish

Authors: Jelínková Štěpánka | Carneiro Diana | Vieira Madalena | Tichá Lenka | Macák Jan | Roušar Tomáš | Martins Roberto | Pavlaki Maria D.

Year: 2025

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Submicron TiO₂ Rutile Fibers Exhibit No Toxic Effects in Zebrafish	The development, production, and environmental presence of inorganic fibers of various diameters is steadily increasing worldwide implying raising concerns about their potential ecological safety. Despite their growing use, there is still a lack of comprehensive data on their effects on freshwater organisms. Titanium dioxide is widely utilized across industry due to its excellent properties. In this study, newly synthesized TiO2 rutile fibers with an average diameter in the sub-micrometer range produced via centrifugal spinning were evaluated for their potential ecotoxicological effects in zebrafish (Danio rerio) early life stages, i.e. eggs and larvae, as a biological model. The fibers were tested across 0-100 mg·L-1 concentration range. We assessed developmental toxicity (i.e. malformations), biochemical responses (i.e. markers of oxidative stress and neurotoxicity), and molecular alterations at DNA level in zebrafish larvae following exposure. The results showed no observable developmental malformations or statistically significant biochemical or molecular changes in exposed zebrafish larvae. Based on our findings, the tested TiO2 rutile fibers can be considered as non-toxic to Danio rerio under the given experimental conditions.	TiO₂ Rutile Fibers; Toxicity; Zebrafish