Mgr. Jan Čapek, Ph.D.
- jan.capek7@upce.cz
orcid.org/0000-0002-3713-2467-
Department of Biological and Biochemical Sciences (30440)
Faculty of Chemical Technology
researcher -
- Professional profile
- Publications
Education and academic qualifications
Titul
Mgr.
Rok
2015
Obor
Bioanalytik
Škola
Univerzita Pardubice
Titul
Ph.D.
Rok
2020
Obor
Analytická chemie
Škola
Univerzita Pardubice
Job overview
Od (rok)
2017
Zastávaná pozice
Vědecký pracovník
Zaměstnavatel
Univerzita Pardubice
Publications
| BENEK, O. - VASKOVA, M. - MISKERIKOVA, M. - SCHMIDT, M. - ANDRYS, R. - ROTTEROVA, A. - SKARKA, A. - HATLAPATKOVA, J. - ZDAROVA KARASOVA, J. - MEDVECKY, M. - HROCH, L. - VINKLAROVA, L. - FISAR, Z. - HROUDOVA, J. - HANDL, J. - ČAPEK, J. - ROUŠAR, T. - KOBRLOVA, T. - DOLEZAL, R. - SOUKUP, O. - AITKEN, L. - GUNN-MOORE, F. - MUSILEK, K. Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation European Journal of Medicinal Chemistry, 2023, vol. 258, no. October, s. 115593. ISSN: 0223-5234. | |
| SOPHA, H. - BÁČOVÁ, J. - BAISHYA, K. - SEPULVEDA SEPULVEDA, L. - RODRIGUEZ PEREIRA, J. - ČAPEK, J. - HROMÁDKO, L. - ZAZPE, R. - THALLURI, S. - MISTRÍK, J. - KNOTEK, P. - ROUŠAR, T. - MACÁK, J. White and black anodic TiO2 nanotubes: Comparison of biological effects in A549 and SH-SY5Y cells Surface and Coatings Technology, 2023, vol. 462, no. June, s. 129504. ISSN: 0257-8972. | |
| SVOBODOVA, B. - PULKRABKOVA, L. - PANEK, D. - MISIACHNA, A. - KOLCHEVA, M. - ANDRYS, R. - HANDL, J. - ČAPEK, J. - NÝVLTOVÁ, P. - ROUŠAR, T. - PRCHAL, L. - HEPNAROVA, V. - HRABINOVA, M. - MUCKOVA, L. - TOSNEROVA, D. - KARABANOVICH, G. - FINGER, V. - SOUKUP, O. - HORAK, M. - KORABECNY, J. Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease International Journal of Molecular Sciences, 2023, vol. 24, no. 11, s. 9124. ISSN: 1661-6596. | |
| ROUŠAR, T. - HANDL, J. - ČAPEK, J. - NÝVLTOVÁ, P. - ROUŠAROVÁ, E. - KUBÁT, M. - ŠMÍD, L. - VÁŇOVÁ, J. - MALINAK, D. - MUSILEK, K. - ČESLA, P. Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells Archives of Toxicology, 2023, vol. 97, no. 11, s. 2943-2954. ISSN: 0340-5761. | |
| BÁČOVÁ, J. - KNOTEK, P. - KOPECKÁ, K. - HROMÁDKO, L. - ČAPEK, J. - NÝVLTOVÁ, P. - BRŮČKOVÁ, L. - SCHROTEROVA, L. - SESTAKOVA, B. - PALARČÍK, J. - MOTOLA, M. - CIZKOVA, D. - BEZROUK, A. - HANDL, J. - FIALA, Z. - RUDOLF, E. - BÍLKOVÁ, Z. - MACÁK, J. - ROUŠAR, T. Evaluating the Use of TiO2 Nanoparticles for Toxicity Testing in Pulmonary A549 Cells International Journal of Nanomedicine, 2022, vol. 17, no. 2022, s. 4211-4225. ISSN: 1178-2013. | |
| THIRUNAVUKKARASU, G. - BÁČOVÁ, J. - MONFORT, O. - DWORNICZEK, E. - PALUCH, E. - HANIF, M. - RAUF, S. - MOTLOCHOVA, M. - ČAPEK, J. - HENSEL, K. - PLESCH, G. - CHODACZEK, G. - ROUŠAR, T. - MOTOLA, M. Critical comparison of aerogel TiO2 and P25 nanopowders: Cytotoxic properties, photocatalytic activity and photoinduced antimicrobial/ antibiofilm performance Applied Surface Science, 2022, vol. 579, no. March, s. 152145. ISSN: 0169-4332. | |
| HANDL, J. - NÝVLTOVÁ, P. - ČAPEK, J. - ČESLA, P. - HOVSEPYAN, A. - AVETISYAN, S. - MIČÁNKOVÁ, P. - BRŮČKOVÁ, L. - STAŇKOVÁ, P. - KNOTKOVÁ, K. - PETROSYAN, T. - ROUŠAR, T. The comparison of biological effects of bacterial and synthetic melanins in neuroblastoma cells Food and Chemical Toxicology, 2022, vol. 168, no. October, s. 113355. ISSN: 0278-6915. | |
| HANDL, J. - NÝVLTOVÁ, P. - ČAPEK, J. - ROUŠAR, T. Differences in the biological effects of bacterial and synthetic melanin. In Military Medical Science Letters. Brno: Univerzita obrany v Brně, 2022. | |
| TICHÁ, L. - ČAPEK, J. - ROUŠAR, T. - HANDL, J. Charakterizace toxicity vybraných těžkých kovů s využitím moderních bioanalytických metod. In Sborník příspěvků: studentská vědecká odborná činnost 2021/2022. Pardubice: Univerzita Pardubice, 2022. s. 215-221 s. ISBN 978-80-7560-434-7. | |
| ČAPEK, J. - HANDL, J. - NÝVLTOVÁ, P. - ROUŠAR, T. Studying cadmium neurotoxicity in vitro. In Military Medical Science Letters. Brno: Univerzita obrany v Brně, 2022. | |
| MEZEIOVA, E. - JANOCKOVA, J. - ANDRYS, R. - SOUKUP, O. - KOBRLOVA, T. - MUCKOVA, L. - PEJCHAL, J. - SIMUNKOVA, M. - HANDL, J. - MIČÁNKOVÁ, P. - ČAPEK, J. - ROUŠAR, T. - HRABINOVA, M. - NEPOVIMOVA, E. - LUIS MARCO-CONTELLES, J. - VALKO, M. - KORABECNY, J. 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease European Journal of Medicinal Chemistry, 2021, vol. 211, no. February, s. 113112. ISSN: 0223-5234. | |
| ČAPEK, J. - ROUŠAR, T. Detection of Oxidative Stress Induced by Nanomaterials in Cells-The Roles of Reactive Oxygen Species and Glutathione Molecules, 2021, vol. 26, no. 16, s. 4710. ISSN: 1420-3049. | |
| HANDL, J. - MALINAK, D. - ČAPEK, J. - ANDRYS, R. - ROUŠAROVÁ, E. - HAUSCHKE, M. - BRŮČKOVÁ, L. - ČESLA, P. - ROUŠAR, T. - MUSILEK, K. Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening Chemical Research in Toxicology, 2021, vol. 34, no. 3, s. 699-703. ISSN: 0893-228X. | |
| MAJTNEROVÁ, P. - ČAPEK, J. - PETIRA, F. - HANDL, J. - ROUŠAR, T. Quantitative spectrofluorometric assay detecting nuclear condensation and fragmentation in intact cells Scientific Reports, 2021, vol. 11, no. 1, s. 11921. ISSN: 2045-2322. | |
| MOTOLA, M. - ČAPEK, J. - ZAZPE, R. - BÁČOVÁ, J. - HROMÁDKO, L. - BRŮČKOVÁ, L. - NG, S. - HANDL, J. - SPOTZ, Z. - KNOTEK, P. - BAISHYA, K. - MAJTNEROVÁ, P. - PŘIKRYL, J. - SOPHA, H. - ROUŠAR, T. - MACÁK, J. Thin TiO2 Coatings by ALD Enhance the Cell Growth on TiO2 Nanotubular and Flat Substrates ACS Applied Bio Materials, 2020, vol. 3, no. 9, s. 6447-6456. ISSN: 2576-6422. | |
| HANDL, J. - ČAPEK, J. - MAJTNEROVÁ, P. - BÁČOVÁ, J. - ROUŠAR, T. The Effect of Repeated Passaging on the Susceptibility of Human Proximal Tubular HK 2 Cells to Toxic Compounds Physiological Research, 2020, vol. 69, no. 4, s. 731-738. ISSN: 0862-8408. | |
| HANDL, J. - ČAPEK, J. - MAJTNEROVÁ, P. - PETIRA, F. - HAUSCHKE, M. - ROUŠAROVÁ, E. - ROUŠAR, T. Transient Increase in Cellular Dehydrogenase Activity After Cadmium Treatment Precedes Enhanced Production of Reactive Oxygen Species in Human Proximal Tubular Kidney Cells Physiological Research, 2019, vol. 68, no. 3, s. 481-490. ISSN: 0862-8408. | |
| HANDL, J. - ČAPEK, J. - BÁČOVÁ, J. - HROMÁDKO, L. - MACÁK, J. - ROUŠAR, T. Evaluation of the impact of TiO2 and SiO2 nanofibers on the neuronal cells.. In Toxicology Letters. vol. 314(S1) : abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019). Kidlington: Elsevier, 2019. | |
| HANDL, J. - ČAPEK, J. - MAJTNEROVÁ, P. - BRŮČKOVÁ, L. - ROUŠAR, T. Hodnocení změn funkčního stavu lidských proximálních tubulárních buněk. In Bioimplantologie 2019. Brno: MSD, spol. s r.o., 2019. ISBN 978-80-7392-307-5. | |
| HANDL, J. - ČAPEK, J. - MAJTNEROVÁ, P. - ROUŠAR, T. Nefrotoxické působení kadmia u lidských proximálních tubulárních buněk. In Czech Chemical Society Symposium Series. Praha: Česká společnost chemická, 2018. | |
| HAUSCHKE, M. - ROUŠAROVÁ, E. - FLIDR, P. - ČAPEK, J. - LIBRA, A. - ROUŠAR, T. Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells Toxicology in Vitro, 2017, vol. 39, no. March, s. 52-57. ISSN: 0887-2333. | |
| ČAPEK, J. - HAUSCHKE, M. - BRŮČKOVÁ, L. - ROUŠAR, T. Comparison of glutathione levels measured using optimized monochlorobimane assay with those from ortho-phthalaldehyde assay in intact cells Journal of Pharmacological and Toxicological Methods, 2017, vol. 88, no. November, s. 40-45. ISSN: 1056-8719. | |
| ČAPEK, J. - VRBOVÁ, M. - ROUŠAROVÁ, E. - ROUŠAR, T. Využití fluorescenčních sond při hodnocení poškození buněk.. In Studentská vědecká odborná činnost 2014/2015: sborník příspěvků. Pardubice: Univerzita Pardubice, 2015. s. 39-44 s. ISBN 978-80-7395-922-7. | |
| ROUŠAR, T. - VRBOVÁ, M. - ROUŠAROVÁ, E. - ČAPEK, J. - ČESLA, P. Evaluation of use of HK-2 cells for nephrotoxicity testing in vitro.. In Applied Natural Sciences 2015: conference proceedings. Trnava: Univerzita sv. Cyrila a Metoda v Trnave, 2015. s. 137 s. ISBN 978-80-8105-723-6. |
