Phosgene Derivatives for Nanotechnologies
Provider: Grantová agentura ČR
Programme: Standardní projekty (řešení od 1.1.2011)
Implementation period: 01.01.11 - 31.12.13
Workplace:
Fakulta chemicko-technologická - Ústav organické chemie a technologie
Investigator: Sedlák MilošTeam member: Hanusek Jiří | Drabina Pavel | Pejchal Vladimír | Imramovský Aleš
Description:
The proposal submits a concept of application of phosgene processing technology to preparation of new systems with nanostructure properties designed for chemical and medicinal purposes. The proposal makes use of synthetic method of N-carboxanhydrides of amino acids, chloroformates and carbonates for synthesis of substituted block copolymers of poly(ethylene glycols) with poly(amino acids) (PEG-b-p(AA)) and chiral polyamines (PEG-b-pA) with self-assembly properties. It is intended to prepare and characterise their modular sets and derived hybrid nanomaterials with palladium. In the field of nanomedicine, PEG-b-p(AA) are designed for targeting carriers of antibiotics. The efficiency of prepared sets PEG-b-p(AA) and PEG-b-pA and their hybrid nanomaterials for enantioselective catalysis will be tested using aldolisation, epoxidation, and reduction reactions.
The proposal submits a concept of application of phosgene processing technology to preparation of new systems with nanostructure properties designed for chemical and medicinal purposes. The proposal makes use of synthetic method of N-carboxanhydrides of amino acids, chloroformates and carbonates for synthesis of substituted block copolymers of poly(ethylene glycols) with poly(amino acids) (PEG-b-p(AA)) and chiral polyamines (PEG-b-pA) with self-assembly properties. It is intended to prepare and characterise their modular sets and derived hybrid nanomaterials with palladium. In the field of nanomedicine, PEG-b-p(AA) are designed for targeting carriers of antibiotics. The efficiency of prepared sets PEG-b-p(AA) and PEG-b-pA and their hybrid nanomaterials for enantioselective catalysis will be tested using aldolisation, epoxidation, and reduction reactions.
