Near-infrared emitting molecular crystals for next generation imaging (Crystal-NIR)
Provider: Grantová agentura ČR
Programme: Standardní projekty
Implementation period: 01.01.24 - 31.12.26
Workplace:
Fakulta chemicko-technologická - Oddělení technologie organických látek
Investigator: Imramovský AlešTeam member: Pauk Karel
Description:
Despite the exceptional breakthrough that fluorescence has brought in material, biological and medical sciences, the currently used visible spectrum is associated with fundamental limitations. The use of near-infrared (NIR) fluorescence would enable an essential change by enormously increasing detection sensitivity. So far, however, completely suitable substances have not been developed. In this project, we focus on (i) the design supported by quantum chemical calculations, (ii) synthesis and (iii) crystal engineering of new organic compounds that will form well-defined electronically coupled dimers exhibiting intense NIR fluorescence in the solid state. We will design and prepare sterically hindered so-called dual-state emitting donor-acceptor substituted molecules with side groups ensuring the formation of excimers and exciplexes. In this way, we accomplish NIR emission and prevent loss mechanisms. The obtained results will yield materials for use in bio(medical) imaging and medical diagnostics, optoelectronics, data encryption, etc. and an effective strategy for their formulation.
Despite the exceptional breakthrough that fluorescence has brought in material, biological and medical sciences, the currently used visible spectrum is associated with fundamental limitations. The use of near-infrared (NIR) fluorescence would enable an essential change by enormously increasing detection sensitivity. So far, however, completely suitable substances have not been developed. In this project, we focus on (i) the design supported by quantum chemical calculations, (ii) synthesis and (iii) crystal engineering of new organic compounds that will form well-defined electronically coupled dimers exhibiting intense NIR fluorescence in the solid state. We will design and prepare sterically hindered so-called dual-state emitting donor-acceptor substituted molecules with side groups ensuring the formation of excimers and exciplexes. In this way, we accomplish NIR emission and prevent loss mechanisms. The obtained results will yield materials for use in bio(medical) imaging and medical diagnostics, optoelectronics, data encryption, etc. and an effective strategy for their formulation.
