Publication detail

Enzymatically-modified nanofibers for biomedical applications

Authors: Kučerová Jana | Slováková Marcela | Juklíčková Martina | Stránská Denisa | Bílková Zuzana

Year: 2010

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
cze	Enzymově modifikovaná nanovlákna pro biomedicínu	Cílem naší práce je enzymaticky biofunkcionalizovat nově vyvinutá nanovlákna připravená technologií NanospiderTM. Nanovlákna vyrobená touto unikátní technologií založenou na procesu electrospinningu jsou ultra tenká vlákna zvláště významná svým průměrem, velkým speicifickým povrchem a malou velikostí pórů. Naším úkolem bylo imobilizovat trypsin a chymotrypsin na celulózová a chitosanová nanovlákna tak, aby vznikla kovalentní vazba.	nanovlákna; enzymy
eng	Enzymatically-modified nanofibers for biomedical applications	Influence of proteases entrapped in polysaccharide films on cutaneous wound healing has been already tested on mice skin and the results indicate that this system could be new promising approach for wound therapy. The aim of our team is to enzymatically functionalize newly developed nanomaterials like nanofibers prepared by technology NanospiderTM. Nanofibers produced by this unique technology based on electrospinning process are the ultra-fine solid fibers notable for their very small diameters, their large surface area per unit mass and small pore size. The goal of this work was to covalently immobilize trypsin and chymotrypsin on cellulose and chitosan nanofibers, which were chosen for our experiments for its nontoxic, hydrophilic, biocompatible and biodegradable properties. Our results demonstrated that enzyme-immobilized nanofibers could well serve in wound healing applications and drug delivery system.	Enzymatically-modified nanofibers; biomedical applications

Search

Login for students

Login for employees

Publication detail

Departments

Other Parts

Map

Services

Popular Links