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Synthesis and characterization of a pH-sensitive conjugate of isoniazid with Fe3O4@SiO2 magnetic nanoparticles
Year: 2013
Type of publication: článek v odborném periodiku
Name of source: Bioorganic & Medicinal Chemistry Letters
Publisher name: Pergamon-Elsevier Science Ltd.
Place: Oxford
Page from-to: 4692-4695
Titles:
Language Name Abstract Keywords
cze Syntéza a charakterizace pH-senzitivního konjugátu isoniazidu s Fe3O4@SiO2 magnetickými nanočásticemi Sdělení popisuje přípravu acharakterizaci konjugátu isoniazidu (INH) s magnetickými nanočásticemi Fe3O4@SiO2 o velikosti 115 +/- 60 nm. Molekuly INH byly pčřipojeny k povrchu nanočástic kovalentní pH-sensitivní amidinovou vazbou. Konjugát byl charakterizován X-ray difrakcí, SEM, dynamickým rozptylem světla, IR spektroskopií a microanalýzou. Konjugát uvolňoval isoniazid v in vitro podmínkách (pH = 4, 37 C; t(1/2) cca 115 s). Navíc byla cytotoxicita Fe3O4@SiO2-INH konjugátu stanovena na SK-BR-3 buňkách s použitím xCELLigence systému. Tuberkulostatické přípravek; Isoniazid; proléčivo; pH-senzitivita; magnetické nanočástice
eng Synthesis and characterization of a pH-sensitive conjugate of isoniazid with Fe3O4@SiO2 magnetic nanoparticles The Letter describes the preparation and characterization of a conjugate of isoniazid (INH) with magnetic nanoparticles Fe3O4@SiO2 115 +/- 60 nm in size. The INH molecules were attached to the surface of nanoparticles by a covalent pH-sensitive amidine bond. The conjugate was characterized by X-ray diffraction, SEM, dynamic light scattering, IR spectroscopy and microanalysis. The conjugate released isoniazid under in vitro conditions (pH = 4; 37 degrees C; t(1/2) approximate to 115 s). In addition, the cytotoxicity of the Fe3O4@SiO2-INH conjugate was evaluated in SK-BR-3 cells using the xCELLigence system. Tuberculostatic agent; Isoniazid; Prodrug; pH-sensitivity; Magnetic nanoparticle

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