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Inhibitory effect of carbamates in two types of cholinesterases
Year: 2013
Type of publication: článek v odborném periodiku
Name of source: Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
Publisher name: Univerzita Pardubice
Place: Pardubice
Page from-to: 49-56
Titles:
Language Name Abstract Keywords
cze Inhibiční účinnost karbamátů vůči dvěma typům cholinesteráz Byla stanovena inhibiční účinnost substituovaných 3-(diethylaminofenyl)fenyl karbamátů vůči dvěma typům cholinesteráz (acetylcholinesteráze a butyrylcholinesteráze). Inhibiční účinnost byla vyjádřena hodnotou IC50 (50% inhibiční koncentrace). Byla použita modifikovaná spektrofotometrická Ellmanova metoda. Jako substráty byly použity dva estery cholinu. Bylo prokázáno, že zvolené karbamáty jsou docela účinnými inhibitory cholinesteráz. Nejúčinnějším inhibitorem acetylcholinesterázy je 3-(diethylaminofenyl)fenyl karbamát s hodnotou IC50 = 1.52 uM, zatímco nejúčinnějším inhibitorem butyrylcholinesterázy je 3-(diethylaminofenyl) (3-nitrofenyl) karbamát s hodnotou IC50 = 1,70 uM. cholinesterázy, inhibice, karbamáty
eng Inhibitory effect of carbamates in two types of cholinesterases Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50% inhibitory concentration). Modified spectrophotometric Ellman´s method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved, that chosen carbamates are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 uM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3-nitrophenyl) carbamate with the value of IC50 = 1.70 uM. cholinesterases, inhibition, carbamates

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