Publication detail

Synthesis of propargylic alcohols derived from labile chiral molecules - literature survey and experimental aspects

Authors: Imramovský Aleš | Pauk Karel | Eliáš Zdeněk | Pavlík Jan

Year: 2014

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Synthesis of propargylic alcohols derived from labile chiral molecules - literature survey and experimental aspects	Synthesis of racemic mixture of propargylic alcohols starts usually from appropriate dibromo olefin which reacts with a strong base such as BuLi at -78 °C under inert atmosphere, followed by addition of aldehyde. The presence of various chiral compounds (e.g. [Rh((R)-BINAP)]BF4) is characteristic for the enantioselective synthesis. Deep blue compounds are intermediates suitable for various type of C-C bond reaction such as Negishi coupling, or Migita-Kosugi-Stille cross coupling reaction. In general we are looking also for the reaction which are Palladium free and running under mild conditions—see reaction with benzaldehyde.

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