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A study of tablets with a co-processed dry binder containing hypromellose and alpha-lactose monohydrate
Authors: Mužíková J. | Hávová S. | Ondrejček P. | Komersová Alena | Lochař Václav
Year: 2014
Type of publication: článek v odborném periodiku
Name of source: Journal of Drug Delivery Science and Technology
Publisher name: Editions Sante
Place: Paris
Page from-to: 100-104
Titles:
Language Name Abstract Keywords
cze Studium tablet se směsným suchým pojivem na bázi hypromellosy a α-laktózy monohydrátu Práce se zabývá lisovatelností a disolučními vlastnostmi tablet se směsným suchým pojivem RetaLac (α-laktóza monohydrát a hypromellosa v poměru 1:1). Stejné parametry byly studovány u fyzikálních směsí sprejově sušené laktózy Flowlac100 a různých druhů hypromellosy a porovnávány s pojivem RetaLac. RetaLac; hypromellosa; směsná suchá pojiva; energetický profil lisování; pevnost tablet v tahu; uvolňování léčiva; matricové tablety
eng A study of tablets with a co-processed dry binder containing hypromellose and alpha-lactose monohydrate The paper examines the co-processed dry binder RetaLac from the aspect of its compressibility and dissolution of the active ingredient from tablets. RetaLac contains a-lactose monohydrate and hypromellose in the identical proportion. The same parameters are tested in the corresponding physical mixtures of Flowlac100 and various types of hypromellose (Metolose 100SR, Metolose 4000SR, Metolose 100000SR) and compared with the substance RetaLac. Compressibility is evaluated by means of the energy profile of compression and tensile strength of tablets. The values of the total energy of compression and plasticity were higher in the substance RetaLac than in the physical mixtures of lactose and various types of hypromellose: tablet strength, on the contrary, was lower. Dissolution profile of the active ingredient from tablets with RetaLac corresponded to the dissolution profile of tablets from a physical mixture of Flowlac 100 and Metolose 4000SR. RetaLac; Hypromellose; Metolose SR; Co-processed dry binder; Energy profile of compression; Tensile strength of tablets; Drug release; Swellable-matrix tablets

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