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Compressibility of tableting materials and properties of tablets with glyceryl behenate
Authors: Mužíková Jitka | Muchová Sandra | Komersová Alena | Lochař Václav
Year: 2015
Type of publication: článek v odborném periodiku
Name of source: Acta Pharmaceutica
Publisher name: Croatian Pharmaceutical Society
Place: ZAGREB
Page from-to: 91-98
Titles:
Language Name Abstract Keywords
cze Lisovatelnost tabletovacích materiálů a vlastnosti tablet s glyceryl behenátem Článek studuje lisovatelnost přímo lisovatelných tabletovacích materiálů se suchými pojivy, sprejově sušenou laktózou a mikrokrystalickou celulózou, a glyceryl behenátem při různých koncentracích. Lisovatelnost byla hodnocena pomocí energetického profilu lisování a tenzní síly tablet. Rychlost uvolňování aktivní látky, kyseliny salicylové, byla rovněž testována. lipofilní matricové tablety; glyceryl dibehenát; salicylová kyselina; energetický profil lisování; tenzní síla tablet; disoluční profil
eng Compressibility of tableting materials and properties of tablets with glyceryl behenate The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used. lipophilic matrix tablet; glyceryl dibehenate; salicylic acid; energy profile of compression; tensile strength of tablets; dissolution profile

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