Login for students

Login for employees

Publication detail

Henry reaction catalyzed by new series of imidazolidine-4-one Cu-complexes
Authors: Drabina Pavel | Horáková Eva | Růžičková Zdeňka | Sedlák Miloš
Year: 2015
Type of publication: článek v odborném periodiku
Name of source: Tetrahedron Asymmetry
Publisher name: Elsevier Science BV
Place: Amsterdam
Page from-to: 141-147
Titles:
Language Name Abstract Keywords
cze Henryho reakce katalyzovaná novou sériíCu-komplexy imidazolidin-4-onu Byla připravena série 5-terc-butyl-2-(pyridin-2-yl)imidazolidin-4-onů a jejich Cu(II) komplexů, které byly studovány jako enantioselektivní katalyzátory asymetrické Henryho reakce různých aldehydů s nitromethanem. Bylo zjištěno, že tyto sloučeniny fungují jako efektivní katalyzátory s enantiomerním přebytkem až 97%. závisejícím na substituci stereogenního centra a na konfiguraci imidazolidin-4-onu. Nejúčinější derivát byl použit při syntéze Salmeterolu s ee 92%. asymetrická nitroaldolová reakce; kvarterní amoniové soli; alfa-aminokyseliny; měďnaté komplexy; enantioselektivní syntéza; stereoselectivní syntéza; nitroalkany
eng Henry reaction catalyzed by new series of imidazolidine-4-one Cu-complexes A series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-ones have been prepared and their Cu(II) complexes studied as enantioselective catalysts of the asymmetric Henry reaction of various aldehydes with nitromethane. It was found that these compounds were effective catalysts for this reaction, with enantiomeric excesses being as high as 97%. The enantioselectivities of individual derivatives were different and depended on the substituents attached to stereogenic centers and the configuration of imidazolidine-4-one cycle. High enantiomeric excesses were obtained irrespective of the solvent used. The most effective derivative was chosen for preparation of the key intermediate for Salmeterol medical drug and an enantiomeric excess of 92% was obtained. asymmetric nitroaldol reaction; quaternary ammonium-salt; alpha-amino-acids; copper(ii) complexes; enantioselective synthesis; stereoselective-synthesis; efficient synthesis; nef reaction; ligands; nitroalkanes

Departments

Other Parts

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0Creative CommonsAttributionNonCommercialNoDerivatives