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Publication detail

Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product
Authors: Hromadková Lenka | Kolářová Michala | Jankovičová Barbora | Bartoš Aleš | Říčný Jan | Bílková Zuzana | Řípová Daniela
Year: 2015
Type of publication: článek v odborném periodiku
Name of source: Journal of Neuroimmunology
Publisher name: Elsevier Science BV
Place: Amsterdam
Page from-to: 121-129
Titles:
Language Name Abstract Keywords
cze Identifikace a charakterizace přirozených protilátek proti tau proteinu v gamaglobulinovém preparátu Jeden z posledních terapeutických přístupů v léčbě Alzheimerovy choroby je použití gamaglobulinového preparátu. Detailní charakterizace přirozeně se vyskytujících protilátek v preparátech typu Flebogama, IVIG je jednoznačně prospěšná. Zaměřili jsme se na identifikaci a charakterizaci protilátek proti Tau proteinu, biomarkeru Alzheimerovy choroby. Zaměřili jsme se na distribuci podtříd třídy IgG a sledovali jsme jejich reaktivitu s aviditu k cílovému proteinu - Tau proteinu. Alzheimerova choroba; avidita; imunoreaktivita; intravenózní imunoglobuliny; přirozené protilátky; Tau protein
eng Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product The latest therapeutic approaches to Alzheimer disease are using intravenous immunoglobulin (MG) products. Therefore, the detailed characterization of target-specific antibodies naturally occurring in MG products is beneficial. We have focused on characterization of antibodies isolated against tau protein, a biomarker of Alzheimer's disease, from Flebogamma IVIG product. The analysis of IgG subclass distribution indicated skewing toward IgG3 in anti-tau-enriched IgG fraction. The evaluation of their reactivity and avidity with several recombinant tau forms was performed by ELISA and blotting techniques. Truncated non-phosphotylated tau protein (amino acids 155-421) demonstrated the highest reactivity and avidity index. We provide the first detailed insight into the reactivity of isolated natural antibodies against tau protein. Alzheimer disease; Avidity; Immunoreactivity; Intravenous immunoglobulins; Natural antibodies; Tau protein

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