Publication detail

Series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one Cu-complexes as new catalysts for Henry reaction

Authors: Horáková Eva | Nováková Gabriela | Drabina Pavel | Sedlák Miloš

Year: 2016

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one Cu-complexes as new catalysts for Henry reaction	The aim of this work was preparation of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one derivatives 1-3 and their corresponding Cu(II) complexes. These compounds were studied as enantioselective catalysts for the asymmetric Henry reaction of various aldehydes with nitromethane. It was found the 5-tert-butyl derivatives are effective catalysts for this reaction, with enantiomeric excesses being as high as 97%. The enantioselectivities of individual derivates 1-3 are different and depend on the alkyl substituents attached to stereogenic centres and the configuration of imidazolidine-4-one cycle. The most efficient derivative was found to be the Cu(II)-complex of derivative 1. Its enantiocatalytic activity is comparable with the best so far known enantioselective catalysts of the Henry reaction.

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