Publication detail

Influence of alcohol and pepsine presence on tramadol hydrochloride release from hydrophilic matrix tablets

Authors: Myslíková Kateřina | Komersová Alena | Lochař Václav | Mužíková J

Year: 2016

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Influence of alcohol and pepsine presence on tramadol hydrochloride release from hydrophilic matrix tablets	The aim of this work is study of influence of alcohol and pepsine on tramadol hydrochloride release from hydrophilic matrix tablets in simulated gastric fluid (SGF). In acidic medium and SGF (without alcohol and pepsin), the higher drug release rate was found for the formulations containing co-processed dry binder Disintequik™ MCC 25 in comparison with the tablets containing Prosolv® SMCC 90. Drug release rate is also influenced by viscosity grade of used MethocelTM Premium CR (K4M - higher release rate of TH). For all formulations, addition of alcohol into the acidic medium don’t influence the drug dissolution profile and drug release rate. But the differences in kinetic profiles of formulations containing Prosolv® SMCC 90 and Disintequik™ MCC 25 were found after the pepsin addition into SGF. Pepsin presence in SGF decreases release rate of TH from formulations containing Disintequik™ MCC 25.	tramadol hydrochloride; dissolution; formulation

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