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Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
Authors: Komersová Alena | Lochař Václav | Myslíková Kateřina | Mužíková Jitka | Bartoš Martin
Year: 2016
Type of publication: článek v odborném periodiku
Name of source: European Journal of Pharmaceutical Sciences
Page from-to: 36-45
Titles:
Language Name Abstract Keywords
cze Formulace a disoluční kinetická studie hydrofilních tablet s tramadol hydrochloridem a různými směsnými suchými pojivy Cílem této studie je možnost použití směsných suchých pojiv ve formulaci tablet s řízeným uvolňováním léčiva. Hydrofilní tablety s tramadol hydrochloridem, hypromelózou a různými směsnými pojivy byly připraveny přímým lisováním. suchá pojiva; disoluční kinetika; hypromelóza; tablety; tramadol hydrochlorid
eng Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel™ Premium CR cannot control the tramadol release effectively for > 12 h and tablets containing Disintequik™ MCC 25 and Methocel™ Premium CR > 8 h. Co-processed dry binders; Dissolution kinetics; Hypromellose; Matrix tablets; Tramadol hydrochloride

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