Publication detail

Study of dual matrix tablets containing hypromellose of different viscosity degree and glyceryl dibehenate

Authors: Mužíková Jitka | Holubová Kateřina | Komersová Alena | Lochař Václav

Year: 2016

Type of publication: článek v odborném periodiku

Name of source: Acta Poloniae Pharmaceutica

Page from-to: 461-468

Titles:

Language	Name	Abstract	Keywords
cze	Studie duálních tablet obsahujících hypromelózu různého viskozitního stupně a glyceryl dibehenát	Studie se zabývá lisovatelností přímo lisovaných tablet obsahujících hypromelózu a glyceryl dibehenát.	duální tablety; energetický profil lisování; glyceryl dibehenát; hypromelóza; rozpouštěcí kinetika; tenzní síla tablet
eng	Study of dual matrix tablets containing hypromellose of different viscosity degree and glyceryl dibehenate	Studies are described on the compressibility of directly compressible tableting materials containing two viscosity types of hypromellose in two concentrations and tableting materials containing additional glyceryl dibehenate, also in two concentrations. Compressibility is evaluated by means of the energy profile of the compression process and determination of tensile strength of tablets. Dissolution test examines the rate of release of the active ingredient from matrix tablets, which is subsequently evaluated mathematically. Increased concentrations of both hypromelloses and an addition of glyceryl dibehenate into tablets with both types of hypromellose improved compressibility. The rate of drug release was decreased with increasing viscosity degree of hypromellose and its increasing concentration. An addition of glyceryl dibehenate exerted the same influence on release as increased concentrations of the pertinent hypromellose.	Dual matrix tablets; Energy profile of compression; Glyceryl dibehenate; Hypromellose; Release kinetics; Tensile strength of tablets

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