Publication detail

Dendrimers as a key component of detection probes in various bioapplications

Year: 2017

Type of publication: ostatní - článek ve sborníku

Name of source: YISAC 2017 24th Young Investigators Seminar on Analytical Chemistry : book of abstracts

Publisher name: Ca’ Foscari University of Venice

Place: Benátky

Page from-to: 5

Titles:

Language	Name	Abstract	Keywords
eng	Dendrimers as a key component of detection probes in various bioapplications	Hyperbranched polymeric 3D structures are known as dendrimers which name reflecting its structure reminding crown tree and its branches. This structure typically contains central molecule forming core. Crown of the dendrimers is formed by cascade branching outwards from the core. Exactly defined amount of amino, carboxyl, hydroxyl or other functional groups, usually located on the top of the dendrimers, allowing attachment of high amounts of various molecules (enzymes, drugs, antibodies, etc.) to gain highly biofunctionalized carriers for further applications. Due to functionalization of dendrimers raise its usefulness thanks to good water solubility and biocompatibility, up to now dendrimers have been used in many biomedical applications in immunology, drug delivery, tissue engineering, gene therapy/delivery or as well as catalysts in industry, pigments or optoelectronics. Dendrimers found applicability also in luminescence detection or electrochemical biosensors. Our work deals with incorporation of fluorescence tags to polyamidoamine (PAMAM) dendrimers. Prepared probes are suitable for fluorescence detection or detection by electrochemical biosensors.	Dendrimers; detection; probes; bioapplications

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