Publication detail

Enantioselective catalysts for Henry reaction based on copper(II) complexes of 2-(pyridine-2-yl)imidazolidine-4-thione

Authors: Nováková Gabriela | Drabina Pavel | Sedlák Miloš

Year: 2017

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Enantioselective catalysts for Henry reaction based on copper(II) complexes of 2-(pyridine-2-yl)imidazolidine-4-thione	The products of the asymmetric Henry reaction are non-racemic β-nitroalcohols, which represent important building blocks designed for the synthesis of many pharmaceutical products. [1] Therefore, Henry reaction is one of the most intensively studied asymmetric reaction, used for evaluation of known or newly prepared enantioselective catalysts. [2,3] Among highly enantioselective catalysts of Henry reaction belong chiral Cu(II) complexes. The aim of this work was preparation of new series of substituted 2-(pyridine-2-yl)imidazolidine-4-thione, and study of catalytic activity of their Cu(II) complexes in Henry reaction. It was found out, that the most efficient catalyst provided corresponding 2-nitroalcohols with enantioselectivity up to 98 % ee. Finally, the imidazolidine-4-thione catalysts were immobilized by anchoring on polymeric carriers (e.g. chloromethylated polystyrene). The catalytic activity and recyclability of immobilized forms of catalysts were also studied. [4]	Henry reaction, β-nitroalcohols, assymetric, enantioselective catalysts, 2-(pyridine-2-yl)imidazolidine-4-thione

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