Publication detail

Alfaprostol: new strategy for the synthesis of ω-chain

Authors: Agostinho Monteiro Sara Eunice | Imramovský Aleš | Pauk Karel | Pavelová R | Pavlík J

Year: 2017

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	Alfaprostol: new strategy for the synthesis of ω-chain	The formation of a new C-C bond between a Corey lactone derivative and an adequate chloride has been studied. In a first approach Sonogashira coupling conditions have been considered, however the results were disappointed and desired intermediate was not obtained. In a second attempt cross-coupling under Stille conditions using an alkynylstannane derivative has been studied. Those conditions have proved to be an adequate methodology to the synthesis of key intermediates with a propargyl ketone skeleton.	alfaprostol; prostaglandin; Corey lactone; Sonogashira coupling; Stille coupling

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