Publication detail

Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

Year: 2017

Type of publication: článek v odborném periodiku

Name of source: LETTERS IN DRUG DESIGN & DISCOVERY

Publisher name: Bentham Science Publishers Ltd.

Place: Sharjah

Page from-to: 662-671

Titles:

Language	Name	Abstract	Keywords
cze	Syntéza a antiproliferativní aktivity nových O-benzylsalicylamidových derivátů	Na základě toho, že různé substituované salicylamidy vykazují zajímavé biologické vlastnosti, navrhli jsme a syntetizovali nové salicylamidové deriváty s dipeptidovými skupinami.	Salicylamidy; antiproliferační aktivita; cytotoxicita; farmakologická aktivita; aminy
eng	Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives	Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties. Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds. Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI(50) values in the mid-micromolar range.	Salicylamides; antiproliferative activity; cytotoxic activity; pharmacological activity; amines

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