Publication detail

Effect of alcohol on tramadol hydrochloride release from controlled release formulations containing co-processed dry binders

Authors: Myslíková Kateřina | Komersová Alena | Lochař Václav | Mužíková Jitka

Year: 2017

Type of publication: ostatní - článek ve sborníku

Name of source: Proceedings of the 5th International Conference on Chemical Technology

Publisher name: Česká společnost průmyslové chemie

Place: Praha

Page from-to: 433-438

Titles:

Language	Name	Abstract	Keywords
eng	Effect of alcohol on tramadol hydrochloride release from controlled release formulations containing co-processed dry binders	The effect of alcohol on tramadol hydrochloride (TH) release from hydrophilic matrix tablets containing coprocessed dry binder DisintequikTM MCC 25 and hypromellose in different viscosity degrees (as retarding component) was studied due to possibility of dose dumping effect. The release of TH from prepared drug formulations was studied by the dissolution test method using rotating basket apparatus. Dissolution test was performed in acidic medium (pH 1.2), in simulated gastric fluid (SGF) and in SGF containing 5% (v/v) of alcohol. The released amount of TH was determined using UV VIS spectroscopy at wavelength of 271 nm. Obtained dissolution profiles was evaluated by non-linear regression analysis. It was found that the presence of alcohol influeces the release rate of TH from studied formulations only in pepsin presence. The cumulative amount of TH released in 24 h is lower in comparison with acidic medium.	co-processed dry binders; matrix tablets; alcohol, pepsin; simulated gastric fluid

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