Publication detail

New synthetic approach for synthesis of alfaprostol propargylic moiety

Authors: Agostinho Monteiro Sara Eunice | Imramovský Aleš | Pauk Karel | Pavelová Radka | Pavlík Jan

Year: 2018

Type of publication: ostatní - přednáška nebo poster

Page from-to: nestránkováno

Titles:

Language	Name	Abstract	Keywords
eng	New synthetic approach for synthesis of alfaprostol propargylic moiety	The synthesis of Prostaglandins has been a challenge over than 40 years. The complex structure, including a cyclopentane ring with two lateral chains, associated with the presence of several chiral centers contributes for the difficulty of the process. Our group is developing a new methodology for the synthesis of alfaprostol omega-chain, a non-halogenated Prostaglandin F2α analogue with luteolytic activity. Literature described two main methodologies for preparation of optically active propargylic alcohols, namely: asymmetric reduction of a propargyl ketone or the asymmetric alkynylation of a carbonyl group.	alfaprostol; prostaglandin; luteolytic activity

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