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Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release
Authors: Muzikova Jitka | Komersová Alena | Lochař Václav | Vildova Lucie | Vošoustová Bára | Bartoš Martin
Year: 2018
Type of publication: článek v odborném periodiku
Name of source: Acta Pharmaceutica
Publisher name: Croatian Pharmaceutical Society
Place: ZAGREB
Page from-to: 295-311
Titles:
Language Name Abstract Keywords
cze Srovnávací studie použití suchých pojiv ve fyzikální směsi a v koprocesované formě v matricových tabletách s prodlouženým uvolňováním léčiva Studie porovnává vlastnosti přímo lisovatelných tabletovacích materiálů a matricových tablet obsahujících kombinaci monohydrátu laktózy a mikrokrystalické celulózy v poměru 3:1 ve fyzikální směsi nebo v koprocesované podobě. Testovány byly tokové vlastnosti, lisovatelnost, pevnost připravených tablet a disoluční chování. Disoluční profily byly vyhodnoceny nelineární regresní analýzou. koprocesovaná suchá pojiva; matricové tablety; polyvinylalkohol; energetický profil lisování; tenzní síla tablet; disoluční testování
eng Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of a-lactose monohydrate and microcrystalline cellulose in the 3: 1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable. coprocessed dry binder; matrix tablets; polyvinyl alcohol; energy profile of compression; tensile strength of tablets; dissolution testing

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