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The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets
Authors: Komersová Alena | Lochař Václav | Myslíková Kateřina | Mužíková Jitka | Bartoš Martin
Year: 2018
Type of publication: článek v odborném periodiku
Name of source: Acta Poloniae Pharmaceutica - Drug Research
Page from-to: 1223-1231
Titles:
Language Name Abstract Keywords
cze Vliv koprocesovaného směsného suchého pojiva s mikrokrystalickou celulózou na uvolňování verapamil hydrochloridu z hydrofilních matricových tablet Cílem studie bylo vyhodnotit možnost použití pojiv MicroceLac 100 (laktóza a mikrokrystalická celulóza v poměru 3:1) a Comprecel 102 (čistá mikrokrystalická celulóza) ve formulacích s prodlouženým uvolňováním verapamil hydrochloridu. Na základě regresní analýzy disolučních profilů bylo zjištěno, že formulace obsahující MicroceLac 100 uvolňují verapamil hydrochlorid rychleji než formulace s čistou mikrokrystalickou celulózou. Bobtnání, eroze a dezintegrace tablet během disolučního testu byly sledovány fotograficky. verapamil hydrochlorid; hypromelóza; Comprecel; MicroceLac; matricové tablety; disoluční kinetika
eng The effect of co-processed dry binder with microcrystalline cellulose on release of verapamil hydrochloride from hydrophilic matrix tablets The aim of this study was to evaluate the use of co-processed dry binder MicroceLac100 (lactose and microcrystalline cellulose in ratio 3 : 1) and Comprecel 102 (pure microcrystalline cellulose) in formulations for the extended release of verapamil hydrochloride. Hydrophilic matrix tablets containing verapamil hydrochloride, hypromellose and dry binder were prepared by the direct compression method. Hypromelloses MethocelTM K4M Premium CR or MethocelTM K100M Premium CR were used as controlled release agents. Using scanning electron microscopy regular distribution of the active substance in the prepared tablets was confirmed. Release of verapamil hydrochloride from the prepared formulations was studied by the dissolution test method. The dissolution profiles were fitted to the first-order kinetic model, Higuchi diffusion model, Korsmeyer-Peppas and Weibull model and kinetic parameters as the first order release rate constant (k1), release exponent (n) from Korsmeyer-Peppas model, Higuchi constant (KH) and parameters of Weibull model (b, λ) were determined. Based on the results of non-linear regression analysis, the higher release rate constants were found for formulations containing co-processed dry binder MicroceLac100 in comparison with formulations containing pure microcrystalline cellulose (Comprecel 102). In addition, tablets swelling, erosion and disintegration during the dissolution test were monitored photographically. Verapamil hydrochloride; hypromellose; Comprecel; MicroceLac; matrix tablets; dissolution kinetics

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