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Regresní analýza disolučního profilu léčiva a odhad mechanismu uvolňování léčiva
Authors: Muselik Jan | Komersová Alena | Lochař Václav | Kubova Katerina
Year: 2019
Type of publication: článek v odborném periodiku
Name of source: Chemické listy
Publisher name: Česká společnost chemická
Place: Praha
Page from-to: 328-336
Titles:
Language Name Abstract Keywords
cze Regresní analýza disolučního profilu léčiva a odhad mechanismu uvolňování léčiva Kvantitativní analýza disolučních dat na základě matematického popisu disolučního profilu léčiva umožňuje určit mechanismus uvolňování léčiva a získat kinetické parametry uvolňování léčiva v podmínkách in vitro, které mohou být využity např. pro predikci mechanismu a rychlosti uvolňování léčiva v podmínkách in vivo. disoluce; matematický model; nelineární regresní analýza
eng Regression Analysis of the Drug Dissolution Profile and Estimation of The Drug Release Mechanism A drug dissolution profile is one of the most important characteristics of the dosage form with controlled drug release. Obtained dissolution data can be used for evaluation of a drug release rate and mechanism of its release from the dosage form. Nowadays various mathematical models can be used for this purpose. An accordance with a particular mathematical model is determined by regression characteristics and by the relevance of the regression model parameter estimation. Since the dissolution curves are not linear with the exception of the zeroorder kinetics, the transformation of dependencies into a linear form is often performed. However, linearization is connected with a change in the deviation magnitudes and the resulting function does not minimize squared deviations. The main aim of this manuscript was to show an overview of basic mathematical models in a form suitable for nonlinear regression which work with original experimental data and to summarize basic steps for determining the drug release mechanism and rate constants. disoluce; matematický model; nelineární; regresní analýza

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